Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury

Written By David Ritter

David M Ritter, Benjamin M Zemel, Tamara J Hala, Michael E O'Leary, Angelo C Lepore, Manuel Covarrubias

J Neurosci. 2015 Jan 21;35(3):1260-73. doi: 10.1523/JNEUROSCI.1594-14.2015.

Here we showed that different phenotypes of Kv3.4 channel inactivation correlate with variable states following spinal cord injury. We propose that these different channel phenotypes underlie chronic pain responses.

https://www.jneurosci.org/content/35/3/1260.long

David Ritter
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Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels
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Kv3.4 channel function and dysfunction in nociceptors