Estradiol- and Progesterone-Associated Changes in microRNA-Induced Silencing and Reduced Antiseizure Efficacy of an Antagomir in Female Mice
Durgesh Tiwari, Valerine Rajathi, Jeffrey K Rymer, Lindsay N Beasley, Amanda M McGann, Alexander T Bunk, Emma V Parkins, McKenzie F Rice, Katie E Smith, David M Ritter, Angela R White, Carolyn M Doerning, Christina Gross
eNeuro. 2023 Jul 24;10(7):ENEURO.0047-22.2023. doi: 10.1523/ENEURO.0047-22.2023. Print 2023 Jul.
Laboratory investigation showing that estradiol and progesterone alter microRNAs involved in the regulation of seizures. Specifically microRNAs regulating Kv4.2 channel function are controlled by hormonal changes. This has impact on the interpretation of animal models of seizures, treatment possibilities, and catamenial epilepsy.
